Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain
نویسندگان
چکیده
منابع مشابه
Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain
INTRODUCTION The application of high-throughput genomic approaches has revealed 24 novel risk loci for Alzheimer's disease (AD). We recently reported that the bridging integrator 1 (BIN1) risk gene is linked to Tau pathology. RESULTS We used glutathione S-transferase pull-down assays and nuclear magnetic resonance (NMR) experiments to demonstrate that BIN1 and Tau proteins interact directly a...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2015
ISSN: 2051-5960
DOI: 10.1186/s40478-015-0237-8